Strategies for development of hypoallergenic wheat genotypes
Jacek Waga
j.waga@ihar.edu.plZakład Oceny Jakości i Metod Hodowli Zbóż, IHAR, Kraków (Poland)
Jerzy Zientarski
Zakład Oceny Jakości i Metod Hodowli Zbóż, IHAR, Kraków (Poland)
Abstract
Gliadins are one of the most important components in many foodstuffs produced from wheat seed, so they play a significant role in the human diet. However, for people suffering gluten intolerance they may be strong food allergens and in the case of celiac patients – even toxic. This is a serious problem connected with food safety and quality. Immunoreactivity of gliadins extracted from chosen wheat genotypes (species, cultivars and hybrid lines) was investigated. Based on ELISA and skin prick tests binding of gliadin proteins with specific antigliadin antibodies as well as human sera containing IgE antibodies to gluten was analysed. Hybrid genotypes containing a unique composition of gliadins coded by chromosomes 1B and 1D were identified. They showed decreased immunoreactivity in comparison with parental forms. Similar effect was observed in the case of wild progenitors of common wheat: Triticum monococcum and Triticum dicoccum. Differentiation of the analysed wheat species and lines in respect of immunoreactive properties suggest possibility of using genetics and plant breeding methods in production of new hypoallergic wheat genotypes.
Supporting Agencies
Keywords:
gliadins, celiac, allergiesReferences
Bürk K., Melms A., Schulz J. B., Dichgans J., Effectiveness of Intravenous Immnoglobulin therapy in cerebellar ataxia associated with gluten sensitivity. Ann. Neurol., 2001, 50 (6), 827 — 828.
Google Scholar
Brown T. A. 2001. Genomy. Wydawnictwa Naukowe PWN. Warszawa: 85 — 110.
Google Scholar
Buchanan B., Adamidi C., Lozano R. M., Yee B. C., Momma M., Kobrehel K., Ermel R., Frick O. L. 1997. Thioredoxin-linked mitigation of allergic responses to wheat. Proc. Natl. Acad. Sci. Vol 94: 5372 — 5377.
Google Scholar
Buchanan B., Kobrehel K., Yee B. C., Lozano R., Frick O. L., Ermel R. 2001. Neutralization of food allergens by thioredoxin. U.S. patent No. 6,190,723 B1.
Google Scholar
Czerwionka-Szaflarska M., Muller L. 2001. Alergiczne podłoże chorób przewodu pokarmowego. Ter. i Leki 51 (4): 15 — 18.
Google Scholar
De Ritis G., Auricchio G., Jones H. H., Lew E. J. L., Bernardin J. E., Kasarda D. D., In vitro (organ culture) studies of the toxicity of specific A-gliadin peptides in celiac disease. Gastroenterology, 1988, 94, 41 — 49.
Google Scholar
Green P.H.R., Jabri B. 2003. Celiac disease. Lancet Vol. 362: 383 — 391.
Google Scholar
Ikezawa Z., Tsubaki K., Yokota S. 1994. Effect of hypoallergenic wheat (HAW-A1) on atopic dermatitis (AD) with wheat allergy, and its antigenic analysis using sera from patients with AD. Acta Derm. Venerol. 43(6):679 — 688.
Google Scholar
Joint FAO/WHO Food Standards Programme. Codex Alimentarius Commission. Codex Stan, 1981: 118.
Google Scholar
Kasarda D. D. 1994. Toxic cereal grains in celiac disease. Conleth Feighery and Cliona O'Farrelly Editors, Proceedings of the Sixth International Symposium on Celiac Disease held at Trinity College, Dublin in July 1992: 203 — 220.
Google Scholar
Kobrehel K., Wong J. H., Balogh K., Kiss E., Yee B. C., Buchanan B. B. 1992. Specific reduction of wheat storage proteins by thioredoxin h. Plant Physiol. 99: 919 — 924.
Google Scholar
Kuipers A. G. J., Jacobsen E., Visser G. F. 1997. Applications of antisense technology in plants. in: Antisense technology: a practical approach. Lichtenstein C., Nellen W. (eds.) IRL Press at Oxford University Press: 191 — 219.
Google Scholar
Mc Mowat A. 2003. Coeliac disease — a meeting point for genetics, immunology and protein chemistry. Lancet, Vol. 361: 1290 — 1292.
Google Scholar
Palosuo K., Varionen E., Kekki O. M., Klemola T., Kalkkinen N., Alenius H., Reunala T. 2001. Wheat ω-5 gliadin is a major allergen in children with immediate allergy to ingested wheat. J. Allergy Clin. Immunol. Vol.108, No.4:634 — 638.
Google Scholar
Rujner J. 1993. Celiakia — postacie kliniczne i rozpoznawanie. Klinika, Vol. 2, No. 4 (8): 24 — 26.
Google Scholar
Shou-Wang Q., Bergseng E., Molberg Q., Jung G., Fleckenstein B., Sollid L. M. 2005. Refining the rules of gliadin T cell epitope binding to the disease-associated DQ-2 molecule in coeliac disease: importance of proline spacing and glutamine deamidation. J. Immunol. 175: 254 — 261.
Google Scholar
Wong J. H., Kobrehel K., Nimbona C., Yee B. C., Balogh A., Kiss F., Buchanan B. B. 1993. Thioredoxin and bread wheat. Cereal Chem. Vol. 70, No. 1: 113 — 114.
Google Scholar
Vissers M., Doekes G., Heederik D. 2001. Exposure to wheat allergen and fungal α-amylase in the homes of bakers. Clin. Exp. Allergy Vol. 31: 1577 — 1582.
Google Scholar
Zwolińska-Wcisło M., Galicka-Latała D. 2004. Celiakia u dorosłych: rozpoznanie, obraz kliniczny, leczenie. Alergologia, Immunologia. 2, 2/3: 44 — 47.
Google Scholar
Authors
Jacek Wagaj.waga@ihar.edu.pl
Zakład Oceny Jakości i Metod Hodowli Zbóż, IHAR, Kraków Poland
Authors
Jerzy ZientarskiZakład Oceny Jakości i Metod Hodowli Zbóż, IHAR, Kraków Poland
Statistics
Abstract views: 55PDF downloads: 36
License
Copyright (c) 2007 Jacek Waga, Jerzy Zientarski
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Upon submitting the article, the Authors grant the Publisher a non-exclusive and free license to use the article for an indefinite period of time throughout the world in the following fields of use:
- Production and reproduction of copies of the article using a specific technique, including printing and digital technology.
- Placing on the market, lending or renting the original or copies of the article.
- Public performance, exhibition, display, reproduction, broadcasting and re-broadcasting, as well as making the article publicly available in such a way that everyone can access it at a place and time of their choice.
- Including the article in a collective work.
- Uploading an article in electronic form to electronic platforms or otherwise introducing an article in electronic form to the Internet or other network.
- Dissemination of the article in electronic form on the Internet or other network, in collective work as well as independently.
- Making the article available in an electronic version in such a way that everyone can access it at a place and time of their choice, in particular via the Internet.
Authors by sending a request for publication:
- They consent to the publication of the article in the journal,
- They agree to give the publication a DOI (Digital Object Identifier),
- They undertake to comply with the publishing house's code of ethics in accordance with the guidelines of the Committee on Publication Ethics (COPE), (http://ihar.edu.pl/biblioteka_i_wydawnictwa.php),
- They consent to the articles being made available in electronic form under the CC BY-SA 4.0 license, in open access,
- They agree to send article metadata to commercial and non-commercial journal indexing databases.
Most read articles by the same author(s)
- Jacek Waga, Characteristics and inheritance of gliadin proteins in winter wheat genotype coming from Nepal , Bulletin of Plant Breeding and Acclimatization Institute: No. 256 (2010): Regular issue
- Jerzy Zientarski, Jacek Waga, Low molecular weight glutenins as biochemical markes in wheat breeding , Bulletin of Plant Breeding and Acclimatization Institute: No. 244 (2007): Regular issue
- Jacek Waga, Maria Stachowicz, Katarzyna Kraska, Polymorphism of gliadins and HMW glutenins and variability in quality traits in hybrid genotypes of spelt and common wheat , Bulletin of Plant Breeding and Acclimatization Institute: No. 253 (2009): Regular issue
- Jacek Waga, Jerzy Zientarski, Maciej Szaleniec, Andrzej Skoczowski, Efficiency of Poroshell type chromatogrphic columns for wheat gliadin separation using RP-HPLC , Bulletin of Plant Breeding and Acclimatization Institute: No. 260/261 (2011): Regular issue
- Krystyna Witkowska, Edward Witkowski, Tadeusz Śmiałowski, Jacek Waga, Relationship between wheat storage proteins and winter hardiness in chosen hybrids of winter wheat , Bulletin of Plant Breeding and Acclimatization Institute: No. 268 (2013): Regular issue
- Jacek Waga, Catalogue of gliadin protein blocks occurring in Polish common wheat cultivars and strains (Triticum aestivum L.) , Bulletin of Plant Breeding and Acclimatization Institute: No. 243 (2007): Regular issue